Richard S Jope Selected Research

Glycogen Synthase (Synthase I)

1/2017	Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.
1/2017	Stressed and Inflamed, Can GSK3 Be Blamed?
1/2017	Cotinine administration improves impaired cognition in the mouse model of Fragile X syndrome.
1/2014	Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.
5/2013	Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.
12/2012	Glycogen synthase kinase-3 levels and phosphorylation undergo large fluctuations in mouse brain during development.
1/2011	Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3.
10/2010	Is glycogen synthase kinase-3 a central modulator in mood regulation?
2/2010	Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome.
2/2009	Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity.

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Richard S Jope Research Topics

Disease

8	Inflammation (Inflammations) 10/2020 - 04/2007
8	Mood Disorders (Mood Disorder) 12/2012 - 07/2002
7	Alzheimer Disease (Alzheimer's Disease) 01/2016 - 02/2005
7	Bipolar Disorder (Manic Depressive Psychosis) 01/2016 - 04/2002
6	Fragile X Syndrome (Martin Bell Syndrome) 01/2019 - 02/2010
6	Neuroblastoma 09/2007 - 04/2002
5	Neoplasms (Cancer) 03/2011 - 06/2002
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2016 - 03/2003
2	Cognitive Dysfunction 01/2017 - 01/2014
2	Shock 03/2016 - 05/2015
2	Parkinson Disease (Parkinson's Disease) 01/2016 - 01/2014
2	Multiple Sclerosis 01/2016 - 07/2008
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 05/2013 - 07/2008
2	Mental Disorders (Mental Disorder) 01/2013 - 11/2006
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2013 - 07/2012
2	Septic Shock (Toxic Shock Syndrome) 03/2009 - 08/2005
1	Autoimmune Diseases (Autoimmune Disease) 01/2022
1	Rare Diseases (Rare Disease) 01/2019
1	Major Depressive Disorder (Major Depressive Disorders) 01/2018
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2014
1	Brain Neoplasms (Brain Tumor) 01/2014
1	Central Nervous System Diseases (CNS Diseases) 01/2014
1	Down Syndrome (Down's Syndrome) 01/2014
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2014
1	Type 2 Diabetes Mellitus (MODY) 06/2013
1	Lymphatic Metastasis 10/2012
1	Breast Neoplasms (Breast Cancer) 10/2012
1	Brain Diseases (Brain Disorder) 01/2012
1	Neoplasm Metastasis (Metastasis) 03/2011
1	Demyelinating Diseases (Demyelinating Disease) 07/2008
1	Schizophrenia (Dementia Praecox) 11/2006
1	Hyperglycemia 12/2005
1	Hypoxia (Hypoxemia) 02/2005

Drug/Important Bio-Agent (IBA)

19	Glycogen Synthase (Synthase I)IBA 01/2017 - 07/2002
10	LithiumIBA 01/2016 - 04/2002
8	Glycogen Synthase Kinase 3 betaIBA 01/2007 - 04/2002
6	CytokinesIBA 03/2016 - 08/2008
4	Insulin (Novolin)FDA Link 01/2017 - 12/2005
4	Transcription Factors (Transcription Factor)IBA 01/2017 - 08/2008
4	Proteins (Proteins, Gene)FDA Link 07/2011 - 02/2008
3	Antidepressive Agents (Antidepressants)IBA 10/2020 - 02/2005
3	CamptothecinIBA 03/2011 - 06/2002
3	Serine (L-Serine)FDA Link 07/2010 - 02/2005
3	Valproic Acid (Depakote)FDA LinkGeneric 02/2005 - 04/2002
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2017 - 07/2002
2	EnzymesIBA 01/2016 - 02/2005
2	Interleukin-6 (Interleukin 6)IBA 05/2015 - 03/2009
2	Amphetamine (Amfetamine)FDA LinkGeneric 01/2013 - 07/2012
2	Methylphenidate (Ritalin)FDA LinkGeneric 01/2013 - 07/2012
2	Glycogen Synthase Kinase 3IBA 05/2011 - 01/2011
2	Peptides (Polypeptides)IBA 01/2011 - 07/2008
2	Caspase 3 (Caspase-3)IBA 04/2005 - 03/2003
1	Neutralizing AntibodiesIBA 01/2022
1	SW-100IBA 01/2019
1	Histone Deacetylase 6IBA 01/2019
1	Nootropic Agents (Nootropics)IBA 01/2017
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2017
1	Histones (Histone)IBA 01/2017
1	Small Interfering RNA (siRNA)IBA 01/2017
1	CotinineIBA 01/2017
1	ChemokinesIBA 03/2016
1	Capsules (Microcapsules)IBA 01/2016
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2015
1	InterleukinsIBA 05/2015
1	Phosphotransferases (Kinase)IBA 10/2012
1	DNA Transposable Elements (Element, IS)IBA 10/2012
1	Serotonin (5 Hydroxytryptamine)IBA 01/2012
1	TOR Serine-Threonine KinasesIBA 05/2011
1	Mechanistic Target of Rapamycin Complex 1IBA 05/2011
1	Glycogen Synthase KinasesIBA 05/2011
1	Death Domain ReceptorsIBA 03/2011
1	Histone Deacetylase InhibitorsIBA 03/2011
1	Pharmaceutical PreparationsIBA 01/2011
1	Amyloid (Amyloid Fibrils)IBA 01/2011
1	tau Proteins (tau Protein)IBA 01/2011
1	InterferonsIBA 08/2008
1	Myelin-Oligodendrocyte GlycoproteinIBA 07/2008
1	StaurosporineIBA 09/2007
1	Multifunctional EnzymesIBA 01/2007
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 12/2006
1	Neurotransmitter Agents (Neurotransmitter)IBA 11/2006
1	Streptozocin (Streptozotocin)FDA Link 12/2005
1	Blood Glucose (Blood Sugar)IBA 12/2005
1	LipopolysaccharidesIBA 08/2005
1	RotenoneIBA 04/2005
1	Caspase 2IBA 04/2005
1	Imipramine (Janimine)FDA LinkGeneric 02/2005
1	Protein Isoforms (Isoforms)IBA 02/2005
1	Neuroprotective AgentsIBA 05/2004
1	DNA (Deoxyribonucleic Acid)IBA 03/2003
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 03/2003
1	Nerve Growth Factors (Neurotrophins)IBA 07/2002
1	Carbamazepine (Tegretol)FDA LinkGeneric 04/2002
1	Lamotrigine (Lamictal)FDA LinkGeneric 04/2002

Therapy/Procedure

3	Therapeutics 01/2019 - 04/2007
1	Cranial Irradiation 01/2014